A major study conducted by the Harvard School of Public Health has found a significant link between autism and the exposure of the mother to high levels of air pollution during the third trimester of pregnancy.
Researchers focused on 1,767 children born from 1990 to 2002, including 245 diagnosed with autism. The design of the study and the results rule out many confounding measures that can create a bias, Weisskopf said. The researchers took into account socioeconomic factors that can influence exposure to pollution or play a role in whether a child is diagnosed with autism.
The fact that pollution caused problems only during pregnancy strengthened the findings, since it's unlikely other factors would have changed markedly before or after those nine months, he said in a telephone interview.
The ultimate cause of autism remains a mystery in most cases, said Charis Eng, chairwoman of the Lerner Research Institute's Genomic Medicine Institute at the Cleveland Clinic in Ohio. While the Harvard study isn't definitive and the findings could be coincidental, it's not likely given the large size and the precise results, she said in a telephone interview.
"The truth is there has to be gene and environmental interactions," said Eng, who wasn't involved in the study. "I suspect the fetus already had the weak autism spectrum disorder genes, and then the genes and the environment interacted."
It would be a huge help (and I am not in any way being facetious about this) if Jenny McCarthy and all the other celebrity "vaccines cause autism" folks threw their weight behind cleaning up pollution the way they attacked vaccination. Redeem yourselves. (via @john_overholt)
According to many psychiatrists and brain experts, about one in 10 autistic children sheds symptoms before adulthood. Duke researcher Geraldine Dawson explains that "there is this subgroup of kids who start out having autism and then, through the course of development, fully lose those symptoms." Now they just have to figure out why. From the NYT Magazine: The Kids Who Beat Autism.
In the NY Times, Gareth Cook writes about the advantages some companies have found in employing people with autism.
To his father, Lars seemed less defined by deficits than by his unusual skills. And those skills, like intense focus and careful execution, were exactly the ones that Sonne, who was the technical director at a spinoff of TDC, Denmark's largest telecommunications company, often looked for in his own employees. Sonne did not consider himself an entrepreneurial type, but watching Lars -- and hearing similar stories from parents he met volunteering with an autism organization -- he slowly conceived a business plan: many companies struggle to find workers who can perform specific, often tedious tasks, like data entry or software testing; some autistic people would be exceptionally good at those tasks. So in 2003, Sonne quit his job, mortgaged the family's home, took a two-day accounting course and started a company called Specialisterne, Danish for "the specialists," on the theory that, given the right environment, an autistic adult could not just hold down a job but also be the best person for it.
I particularly liked Tyler Cowen's observations:
Tyler Cowen, an economist at George Mason University (and a regular contributor to The Times), published a much-discussed paper last year that addressed the ways that autistic workers are being drawn into the modern economy. The autistic worker, Cowen wrote, has an unusually wide variation in his or her skills, with higher highs and lower lows. Yet today, he argued, it is increasingly a worker's greatest skill, not his average skill level, that matters. As capitalism has grown more adept at disaggregating tasks, workers can focus on what they do best, and managers are challenged to make room for brilliant, if difficult, outliers. This march toward greater specialization, combined with the pressing need for expertise in science, technology, engineering and mathematics, so-called STEM workers, suggests that the prospects for autistic workers will be on the rise in the coming decades. If the market can forgive people's weaknesses, then they will rise to the level of their natural gifts.
As if there was actually more evidence needed that vaccines don't cause autism, the 1998 British study that linked autism to childhood vaccines was recently discovered to be an elaborate fraud. Not just incorrect, a fraud.
An investigation published by the British medical journal BMJ concludes the study's author, Dr. Andrew Wakefield, misrepresented or altered the medical histories of all 12 of the patients whose cases formed the basis of the 1998 study -- and that there was "no doubt" Wakefield was responsible.
"It's one thing to have a bad study, a study full of error, and for the authors then to admit that they made errors," Fiona Godlee, BMJ's editor-in-chief, told CNN. "But in this case, we have a very different picture of what seems to be a deliberate attempt to create an impression that there was a link by falsifying the data."
The full paper from BMJ is here.
The debate is essentially over and the final word is in: vaccines do not cause autism. The results of a rigorous study conducted over several years were just announced and they confirmed the results of several past studies.
Basically, the final two groups that were studied consisted of 256 children with ASD [autism spectrum disorders] and 752 matched controls. One very interesting aspect that looks as though it were almost certainly placed into the experimental design based on concerns of anti-vaccine advocates like Sallie Bernard is a group of children who underwent regression. Basically, the study examined whether there was a correlation between ASD and TCV [thimerosal-containing vaccines, i.e. mercury-containing vaccines] exposure. It also examined two subsets of ASD, autistic disorder (AD) and ASD with regression, looking for any indication whether TCVs were associated with any of them. Regression was defined as:
"the subset of case-children with ASD who reported loss of previously acquired language skills after acquisition."
Also, when adding up total thimerosal exposure, the investigators also included any thimerosal exposure that might have come prenatally from maternal receipt of flu vaccines during pregnancy, as well as immunoglobulins, tetanus toxoids, and diphtheria-tetanus. In other words, investigators tried to factor in all the various ideas for how TCVs might contribute to autism when designing this study.
So what did the investigators find? I think you probably know the answer to that question. They found nothing. Nada. Zip. There wasn't even a hint of a correlation between TCV exposure and either ASD, AD, or ASD with regression:
"There were no findings of increased risk for any of the 3 ASD outcomes. The adjusted odds ratios (95% confidence intervals) for ASD associated with a 2-SD increase in ethylmercury exposure were 1.12 (0.83-1.51) for prenatal exposure, 0.88 (0.62-1.26) for exposure from birth to 1 month, 0.60 (0.36-0.99) for exposure from birth to 7 months, and 0.60 (0.32- 0.97) for exposure from birth to 20 months."
The last result is a bit of an anomaly in that it implies that exposure to TCVs from birth to 1 month and birth to 7 months actually protects against ASD. The authors quite rightly comment on this result thusly:
"In the covariate adjusted models, we found that an increase in ethylmercury exposure in 2 of the 4 exposure time periods evaluated was associated with decreased risk of each of the 3 ASD outcomes. We are not aware of a biological mechanism that would lead to this result."
So get your kids (and yourselves) vaccinated and save them & their playmates from this whooping cough bullshit, which is actually killing actual kids and not, you know, magically infecting them with autism. Vaccination is one of the greatest human discoveries ever -- yes, Kanye, OF ALL TIME -- has saved countless lives, and has made countless more lives significantly better. So: Buck. Up.
Jonah Lehrer profiles Clay Marzo, a top surfer who also happens to be on the autism spectrum, which has been useful in focusing his attention on surfer but is also a challenge.
It's like everyone else has a bucket for dealing with people and I only got a cup. When my cup gets too full, then I shut down.
In the Chronicle of Higher Education, Tyler Cowen argues that society in general and academia in particular is prejudiced with respect to people with autism and that autism in the academy can be an advantage.
Autism is often described as a disease or a plague, but when it comes to the American college or university, autism is often a competitive advantage rather than a problem to be solved. One reason American academe is so strong is because it mobilizes the strengths and talents of people on the autistic spectrum so effectively. In spite of some of the harmful rhetoric, the on-the-ground reality is that autistics have been very good for colleges, and colleges have been very good for autistics.
In this video, an autistic woman speaks in her native language and then translates it into English. But it's not really a direct translation because, as she states, her language is not limited to expressing her thoughts to other human beings...it's more about her reacting to every element of her environment. More about the video on MetaFilter (one commenter calls the thread "perhaps the most enlightening thing I've ever read on MetaFilter"), including a comment from the video's creator.