kottke.org posts about neuroscience
This video from Kurzgesagt is a great little primer on how the human brain stores memories.
Memory is one of the strangest abilities you possess. Your brain uses an incredibly complex biological system to preserve moments from your past that no longer exist, allowing you to revisit experiences from years ago. But memories are not always recordings of reality. In fact, every time a memory comes under the spotlight of your attention, it can melt and change a tiny bit.
What exactly is a memory, how is a moment in time stored inside your brain, and why does remembering something slowly rewrite the story of your life?
Sleeping cleans your brain. Research suggests that zoning out, daydreaming, and being bored can perform a similar function without the need for deep sleep. So put down that phone occasionally and let your brain chill for a bit.
In a recent bombshell piece for the New Yorker (archive), Rachel Aviv explored the personal journals of the celebrated neurologist and writer Oliver Sacks. What she found was shocking: he had fabricated and embellished some of his most well-known work — like Awakenings and The Man Who Mistook His Wife for a Hat. Sacks himself referred to his “lies” and “falsification” in journal entries.
But, in his journal, Sacks wrote that “a sense of hideous criminality remains (psychologically) attached” to his work: he had given his patients “powers (starting with powers of speech) which they do not have.” Some details, he recognized, were “pure fabrications.” He tried to reassure himself that the exaggerations did not come from a shallow place, such as a desire for fame or attention. “The impulse is both ‘purer’ — and deeper,” he wrote. “It is not merely or wholly a projection — nor (as I have sometimes, ingeniously-disingenuously, maintained) a mere ‘sensitization’ of what I know so well in myself. But (if you will) a sort of autobiography.” He called it “symbolic ‘exo-graphy.’”
Sacks had “misstepped in this regard, many many times, in ‘Awakenings,’” he wrote in another journal entry, describing it as a “source of severe, long-lasting, self-recrimination.”
The author Maria Konnikova discovered Sacks’ work in high school — “it blew my mind”, she writes. After the Aviv piece was published, Konnikova wrote a post about Sacks: The man who mistook his imagination for the truth.
When Joseph Mitchell invents a fishmonger, nobody gets hurt. It’s not journalism. It’s not nonfiction. But it’s not life or death. When Jonah Lehrer invents a quote from Bob Dylan, you can call him a narcissistic idiot for thinking he can get away with fabulizing a living legend whose every word has been studied. It’s not journalism. It’s not nonfiction. But, again, it’s not the end of the world. When Oliver Sacks invents an ability that does not exist or crafts a portrait of his own creation, he is hampering medical progress and tampering with the ethics of his profession. Not all journalistic malfeasance is created equal. There are plenty of shades of grey. But making up medical details is not in the gray zone. It’s malpractice.
Yesterday on her Instagram story, cognitive scientist Lera Boroditsky posted a short clip of a lecture in which she posed an intriguing question: if she switched brains with LeBron James, which of them would win in a 1-on-1 game? Some relevant facts: LeBron is 6’8”, 250 pounds, a 4-time NBA champion, 19-time All-Star, 4-time league MVP, and is the all-time NBA points leader. He also possesses a singular basketball mind:
“I can usually remember plays in situations a couple of years back — quite a few years back sometimes,” James says. “I’m able to calibrate them throughout a game to the situation I’m in, to know who has it going on our team, what position to put him in.
“I’m lucky to have a photographic memory,” he will add, “and to have learned how to work with it.”
Boroditsky is 5’3”, 105 pounds, and by her own admission knows nothing about basketball and has “no hops”. So who would win? Boroditsky’s body with LeBron’s brain or LeBron’s body with Boroditsky’s brain? And why?
Photographs have always been an imperfect reproduction of real life — see the story of Dorothea Lange’s Migrant Mother or Ansel Adams’ extensive dark room work — but the seemingly boundless alterations offered by current & future AI editing tools will allow almost anyone to turn their photos (or should I say “photos”) into whatever they wish. In this video, Evan Puschak briefly explores what AI-altered photos might do to our memories.
I was surprised he didn’t mention the theory that when a past experience is remembered, that memory is altered in the human brain — that is, “very act of remembering can change our memories”. I think I first heard about this on Radiolab more than 16 years ago. So maybe looking at photos extensively altered by AI could extensively alter those same memories in our brains, actually making us unable to recall anything even remotely close to what “really” happened. Fun!
But also, one could imagine this as a powerful way to treat PTSD, etc. Or to brainwash someone! Or an entire populace… Here’s Hannah Arendt on constantly being lied to:
If everybody always lies to you, the consequence is not that you believe the lies, but rather that nobody believes anything any longer. This is because lies, by their very nature, have to be changed, and a lying government has constantly to rewrite its own history. On the receiving end you get not only one lie — a lie which you could go on for the rest of your days — but you get a great number of lies, depending on how the political wind blows. And a people that no longer can believe anything cannot make up its mind. It is deprived not only of its capacity to act but also of its capacity to think and to judge. And with such a people you can then do what you please.
As I said in response to this quote in a post about deepfakes:
This is the incredible and interesting and dangerous thing about the combination of our current technology, the internet, and mass media: “a lying government” is no longer necessary — we’re doing it to ourselves and anyone with sufficient motivation will be able to take advantage of people without the capacity to think and judge.
P.S. I lol’d too hard at his deadpan description of “the late Thanos”. RIP, big fella.
What’s going on in the brains of people who meditate? Anecdotal evidence suggests that meditation does something to people’s minds and bodies…quiets and calms them. In this video, Daniel Goleman reports on research done by his colleague Richard Davidson, a neuroscientist at the University of Wisconsin–Madison. Davidson brought a number of “Olympic level meditators” into his lab and hooked them up to a brain scanner. He found that the brains of these expert meditators have different brain wave patterns than the rest of us.
Perhaps the most remarkable findings in the Olympic level meditators has to do with what’s called a gamma wave. All of us get gamma for a very short period when we solve a problem we’ve been grappling with, even if it’s something that’s vexed us for months. We get about half second of gamma; it’s the strongest wave in the EEG spectrum. We get it when we bite into an apple or imagine biting into an apple, and for a brief period, a split-second, inputs from taste, sound, smell, vision, all of that come together in that imagined bite into the apple. But that lasts very short period in an ordinary EEG.
What was stunning was that the Olympic level meditators, these are people who have done up to 62,000 lifetime hours of meditation, their brainwave shows gamma very strong all the time as a lasting trait just no matter what they’re doing. It’s not a state effect, it’s not during their meditation alone, but it’s just their every day state of mind. We actually have no idea what that means experientially. Science has never seen it before.
Goleman and Davidson have written more about how meditation affects the mind and body in their book, Altered Traits.
Sweeping away common misconceptions and neuromythology to open readers’ eyes to the ways data has been distorted to sell mind-training methods, the authors demonstrate that beyond the pleasant states mental exercises can produce, the real payoffs are the lasting personality traits that can result. But short daily doses will not get us to the highest level of lasting positive change — even if we continue for years — without specific additions. More than sheer hours, we need smart practice, including crucial ingredients such as targeted feedback from a master teacher and a more spacious, less attached view of the self, all of which are missing in widespread versions of mind training.
There’s that pesky deliberate practice popping up again.
Composer Max Richter released Sleep in 2015, but it only recently became available on streaming platforms: Spotify, Amazon, Apple Music, Tidal. The album is 8 hours and 24 minutes long and was designed by Richter as a sleep aid/accompaniment. The composer worked with neuroscientist David Eagleman to align the music with the brain & body’s natural sleep rhythms.
A snack-sized version of Sleep is also available: From Sleep, which clocks in at a mere hour long.
Self Reflected is a project by a pair of artist/scientists that aims to visualize the inner workings of the human brain.
Dr. Greg Dunn (artist and neuroscientist) and Dr. Brian Edwards (artist and applied physicist) created Self Reflected to elucidate the nature of human consciousness, bridging the connection between the mysterious three pound macroscopic brain and the microscopic behavior of neurons. Self Reflected offers an unprecedented insight of the brain into itself, revealing through a technique called reflective microetching the enormous scope of beautiful and delicately balanced neural choreographies designed to reflect what is occurring in our own minds as we observe this work of art. Self Reflected was created to remind us that the most marvelous machine in the known universe is at the core of our being and is the root of our shared humanity.
It’s important to emphasize that these images are not brain scans…they are artistic representations of neural pathways and other structures in the brain.
Self Reflected was designed to be a highly accurate representation of a slice of the brain and is informed by deep neuroscience research to allow it to function as a reliable educational tool as well as a work of art.
Wired recently challenged neuroscientist Bobby Kasthuri to explain what a connectome is to people with five different levels of potential understanding: a 5-year-old, a 13-year-old, a college student, a neuroscience grad student, and an expert neuroscientist. His goal: “every person here can leave with understanding it at some level”.
Watching this, I kept thinking of Richard Feynman, who was particularly adept at describing concepts to non-experts without sacrificing truth or even nuance. See him explain fire, rubber bands, how trains go around curves, and magnets.
In the New Yorker, Michael Specter writes generally about the malleability of memory and specifically about Daniela Schiller’s research on disassociating people’s memories from the feelings they have about them. Simply recalling a memory can change it, and Schiller has found evidence that process can be used to remove the feelings of stress, anxiety, and fear associated with certain memories.
Even so, Schiller entered her field at a fortunate moment. After decades of struggle, scientists had begun to tease out the complex molecular interactions that permit us to form, store, and recall many different types of memories. In 2004, the year Schiller received her doctorate in cognitive neuroscience, from Tel Aviv University, she was awarded a Fulbright fellowship and joined the laboratory of Elizabeth Phelps, at New York University. Phelps and her colleague Joseph LeDoux are among the nation’s leading investigators of the neural systems involved in learning, emotion, and memory. By coincidence, that was also the year that the film “Eternal Sunshine of the Spotless Mind” was released; it explores what happens when two people choose to have all their memories of each other erased. In real life, it’s not possible to pluck a single recollection from our brains without destroying others, and Schiller has no desire to do that. She and a growing number of her colleagues have a more ambitious goal: to find a way to rewrite our darkest memories.
“I want to disentangle painful emotion from the memory it is associated with,” she said. “Then somebody could recall a terrible trauma, like those my father obviously endured, without the terror that makes it so disabling. You would still have the memory, but not the overwhelming fear attached to it. That would be far more exciting than anything that happens in a movie.” Before coming to New York, Schiller had heard — incorrectly, as it turned out — that the idea for “Eternal Sunshine” originated in LeDoux’s lab. It seemed like science fiction and, for the most part, it was. As many neuroscientists were aware, though, the plot also contained more than a hint of truth.
Or rather, protozoan? Toxoplasma gondii is a protozoan parasite which is transmitted from rodents to cats through a crafty mechanism…it makes mice attracted to the smell of cat urine. Mouse goes near cat, cat eats mouse, T. gondii has a new host. From cats, the parasite can jump into humans, where it may be responsible for all sorts of nastiness:
Well, the behavioral influence plays out in a number of strange ways. Toxoplasma infection in humans has been associated with everything from slowed reaction times to a fondness toward cat urine — to more extreme behaviors such as depression and even schizophrenia. And here’s the kicker: Two different research groups have independently shown that Toxo-infected individuals are three to four times as likely of being killed in car accidents due to reckless driving.
And maybe makes us want to invent networking technology and share cool links? In this five-minute talk, Kevin Slavin cleverly connects viral media with T. gondii:
That video was so good, I watched the whole thing twice.
For The Verge, Russell Brandom writes about the increasing use of neural implants to control the symptoms of a variety of diseases, from depression to Parkinson’s to dystonia.
The results are as reliable as flipping a light switch, but even after decades of testing, no one knows exactly why it works. Dr. Kaplitt, the surgeon who installed Rebecca Serdans’ implant, explains it by likening the brain to a collection of electrical circuits. A disorder like dystonia is a failure of those circuits. When you install a brain stimulation device, “it’s presumably blocking abnormal information from getting from one part of the brain to another, or normalizing that information.” But Kaplitt is the first to acknowledge that this is just a theory. “The mechanism by which brain stimulation works is still somewhat unclear and controversial.”
But the lingering questions haven’t slowed down research. There are already patents that would use brain stimulation implants to enhance memory or prevent stuttering, to cure anorexia or bring a person to orgasm. Experimental studies use the device to treat Alzheimer’s disease and drug addiction. Those circuits aren’t as well understood as the circuits governing movement disorders, but the principle is no different. Once you’ve got a line into the circuitry of the brain, Parkinson’s is just the beginning.
Last week I featured a video of a man with Parkinson’s who has a brain pacemaker that allows him to function normally.
There is increasing evidence that a parasite called Toxoplasma gondii, which many humans have gotten from cat feces, can rewire our brains and modify human behavior in unexpected ways.
The parasite, which is excreted by cats in their feces, is called Toxoplasma gondii (T. gondii or Toxo for short) and is the microbe that causes toxoplasmosis-the reason pregnant women are told to avoid cats’ litter boxes. Since the 1920s, doctors have recognized that a woman who becomes infected during pregnancy can transmit the disease to the fetus, in some cases resulting in severe brain damage or death. T. gondii is also a major threat to people with weakened immunity: in the early days of the AIDS epidemic, before good antiretroviral drugs were developed, it was to blame for the dementia that afflicted many patients at the disease’s end stage. Healthy children and adults, however, usually experience nothing worse than brief flu-like symptoms before quickly fighting off the protozoan, which thereafter lies dormant inside brain cells-or at least that’s the standard medical wisdom.
But if Flegr is right, the “latent” parasite may be quietly tweaking the connections between our neurons, changing our response to frightening situations, our trust in others, how outgoing we are, and even our preference for certain scents. And that’s not all. He also believes that the organism contributes to car crashes, suicides, and mental disorders such as schizophrenia. When you add up all the different ways it can harm us, says Flegr, “Toxoplasma might even kill as many people as malaria, or at least a million people a year.”
In a 2008 paper called The Seductive Allure of Neuroscience Explanations, a group from Yale University demonstrated that including neuroscientific information in explanations of psychological phenomena makes the explanations more appealing, even if the neuroscientific info is irrelevant.
Explanations of psychological phenomena seem to generate more public interest when they contain neuroscientific information. Even irrelevant neuroscience information in an explanation of a psychological phenomenon may interfere with people’s abilities to critically consider the underlying logic of this explanation.
I don’t know if I buy this. Perhaps if the authors had explained their results relative to how the human brain functions…
This is incredible…researchers at Berkeley have developed a system that reads people’s minds while they watch a video and then roughly reconstructs what they were watching from thousands of hours of YouTube videos. This short demo shows how it works:
Nishimoto and two other research team members served as subjects for the experiment, because the procedure requires volunteers to remain still inside the MRI scanner for hours at a time.
They watched two separate sets of Hollywood movie trailers, while fMRI was used to measure blood flow through the visual cortex, the part of the brain that processes visual information. On the computer, the brain was divided into small, three-dimensional cubes known as volumetric pixels, or “voxels.”
“We built a model for each voxel that describes how shape and motion information in the movie is mapped into brain activity,” Nishimoto said.
The brain activity recorded while subjects viewed the first set of clips was fed into a computer program that learned, second by second, to associate visual patterns in the movie with the corresponding brain activity.
Brain activity evoked by the second set of clips was used to test the movie reconstruction algorithm. This was done by feeding 18 million seconds of random YouTube videos into the computer program so that it could predict the brain activity that each film clip would most likely evoke in each subject.
Finally, the 100 clips that the computer program decided were most similar to the clip that the subject had probably seen were merged to produce a blurry yet continuous reconstruction of the original movie.
The kicker: “the breakthrough paves the way for reproducing the movies inside our heads that no one else sees, such as dreams and memories”. First time travelling neutrinos and now this…what a time to be alive. (via ★essl)
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