Fuck You by Cee-Lo AUG 23 2010
Great song by Cee-Lo, who you may know as one half of Gnarls Barkley.
NSFW in both the visual and audio departments for extensive use of the phrase "fuck you".
I love Anil's comment that the video is "a little bit Tobias, and a little bit Sasha". And indeed the typeface in the video is Champion Gothic, designed by Tobias Frere-Jones' partner, Jonathan Hoefler.