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How to drink all night without getting drunk

Jim Koch is the co-founder and chairman of The Boston Beer Company, brewer of the Sam Adams beers. Part of his job is to drink professionally and he does so without getting completely sloshed. What’s his secret? Eating a packet of dry yeast before tying one on.

You see, what [expert brewer] Owades knew was that active dry yeast has an enzyme in it called alcohol dehydrogenases (ADH). Roughly put, ADH is able to break alcohol molecules down into their constituent parts of carbon, hydrogen, and oxygen. Which is the same thing that happens when your body metabolizes alcohol in its liver. Owades realized if you also have that enzyme in your stomach when the alcohol first hits it, the ADH will begin breaking it down before it gets into your bloodstream and, thus, your brain.

“And it will mitigate - not eliminate - but mitigate the effects of alcohol!” Koch told me.

Could have used this tip last night. Does this mean no hangovers as well?

Update: I got two kinds of feedback about this post:

1) What’s the fun in drinking alcohol if you’re not getting drunk? (Good point.)

2) Yeast doesn’t really work. What does seem to work is Pepcid AC and Zantac. From Shenglong on Hacker News:

Again, I’m not a chemist or a doctor, but from my preliminary internet research and anecdotal testing (though I have quite a few different data points), Famotadine (OTC) [Pepcid], and higher levels of APO-Ranitidine (can be prescription) [Zantac] seems to slow the rate of ethanol -> acetaldehyde, balancing out the drunkness effect more, and giving you more time to process the acetaldehyde -> acetic acid. I typically go from maxing out at 2 drinks / 3 hour period, to about 11 drinks / 3 hour period on Ranitidine, given favorable conditions. I’ve had lower levels of success with Famotadine.

And it goes without saying, I don’t recommend trying any of this at home. At the local bar on the other hand Nope, not there either. (thx, @natebirdman)