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New antibiotic discovered: teixobactin

posted by Jason Kottke   Jan 08, 2015

Scientists have discovered the first promising new antibiotic in 25 years. And even better, says Ed Yong, is that the antibiotic in question is “resistant to resistance”.

A team of scientists led by Kim Lewis from Northeastern University have identified a new antibiotic called teixobactin, which kills some kinds of bacteria by preventing them from building their outer coats. They used it to successfully treat antibiotic-resistant infections in mice. And more importantly, when they tried to deliberately evolve strains of bacteria that resist the drug, they failed. Teixobactin appears resistant to resistance.

Bacteria will eventually develop ways of beating teixobactin — remember Orgel — but the team are optimistic that it will take decades rather than years for this to happen. That buys us time.

…and also that the process by which teixobactin was discovered is the real breakthrough:

Teixobactin isn’t even the most promising part of its own story. That honour falls on the iChip-the tool that the team used to discover the compound. Teixobactin is a fish; the iChip is the rod. Having the rod guarantees that we’ll get more fish-and we desperately need more.