This is great: "Time seems to speed up as you get older. And you wonder—is it biological, or is it because life had more novelty when you were a child? Travel partly answers this question—with more novelty, time slows way down again."

Everything on this list resonates! I am guilty of #5 and 100% agree with #22

This is a terrific list! I hope readers will add some more of their own.

Well ok then, here are mine:
1. Do a few everyday things whenver you go. Go to the movies, ride the bus or subway, eat at the local fast-food chain.
2. Brush your teeth at the end of a long flight, either prior to landing or upon arrival. Makes a huge difference in feeling good!
3. If you're confused about some local practice or how things work, spend 15 minutes just watching how everyone else does it. This has helped me buying subway tickets in Shanghai and in not getting ripped off by the bag check at Mao's tomb.
4. When you're far from home, try to see the sun rise. Daybreak in an unfamilair place is always memorable. You might even feel like you have Rome (or Rio or Osaka) all to yourself!

Thank you for sharing! Lists like this are a joy.

My tip: Ship stuff home.
Regarding #22. Staying in expensive hotels no longer guarantees places to put your stuff. Super cool glassed-in shower that leaks? Sure. Underwear drawer? Nope.

The tip I always offer: attend a local sporting event. Baseball in Japan, football in England, college basketball in Indiana, hockey in Canada are some of the most memorable experiences I've ever had when traveling. Bull fighting in Mexico was memorable, too, I suppose, but not one I can really recommend.

So we're on a road trip when the host at a B+B tells us what should be the obvious: that there is no"should see". The goal is to do what we'd enjoy doing. At which point she advised us to spend a couple of days in something of a resort for the "natives", not "foreigners". And it was great.
Other thing I enjoy, maybe from growing up as something of an urban rat, is getting feet on the ground--trying to pass as a native, blending in.

My tip would be to sometimes walk around without staring at a map so you can experience the spatial understanding of a city or place, let yourself be lost for a little bit.

From The Onion: Tourist Immediately Breaks 34 Sacred Local Customs While Deboarding Airplane.

Deacon, who somehow had no idea he was being offensive in any way, shape, or form, reportedly wasted no time doing so and, within 30 seconds of unbuckling his seat belt at the gate, had unknowingly violated countless unwritten rules that inhabitants of Japan had observed for thousands of years.

#2 is very important - my girlfriend and I went on a trip with our roommate and her boyfriend and...the approach to vacationing could not have been more different and so all four of us ended up not doing very much because we rarely were on the same wavelength on what we wanted to do.

Since that trip though, I've learned to be much more comfortable on trips to go "Hey, I'm going to go see/do/walk/grab a bite" and then put the ball in others' courts if they want to join or just stay put (or do their own thing!) I also think that helps make the vacation feel a little more casual with some coming and going and less like a tightly scripted field trip (not that there's anything wrong with that).