The Danish Girl is an upcoming film starring Eddie Redmayne as transgender pioneer Lili Elbe, who was one of the first people to undergo gender reassignment surgery. It's based on a novel of the same name which presents a fictionalized account of Elbe's life.
The film may well net Redmayne another Oscar nomination, but I don't know how the transgender community will react. From a quick look on Twitter and the past reception of Oscar-hopeful films dealing with similar issues (see The Imitation Game's portrayal of Alan Turing's sexuality), I'm guessing it may not be so well-received.